von Willebrand disease (VWD) is the most common inherited bleeding disorder caused by mutations in the VWF gene [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], which result in quantitative and/or qualitative defects in VWF [2], [19]. This evidence concerns the gene VWF and hemorrhagic disease.