Most of those DMRs are unique for each AML subtype i.e. DMRs associated with MEIS1/2, TOP3B, CDH13, ST6GAL2 in t(8;12) AML, DOK6, NCOR2 in t(15;17) AML, ELK1, VMO1 in NK AML, SNX16, HHEX in trisomy 8 AML. The gene discussed is TOP3B; the disease is acute myeloid leukemia.