HHEX and acute myeloid leukemia: Since, the HHEX gene (also known as PRH gene) showed a significant methylated CGI located in its gene body (between exon 2 and exon 3) in trisomy 8 AML against the rest of the groups (absolute methylation difference = 0.74, P = 9×10−6) (Dataset S3), we validated the DNA methylation of that island by pyrosequencing (Fig. S10d).