Similar to results observed in human HF hearts [8], [15], we found that, of the PKC isozymes present in rat heart, only PKCβII was activated in the myocardial infarction-induced failed hearts, as evidenced by its increased association with the cell particulate fraction (Fig. 1I); there was also a 3-fold increase in catalytic activity of PKCβII, as compared with that from control rat hearts (Fig. 1J). This evidence concerns the gene PRRT2 and myocardial infarction.