EGF and neoplasm: In the case of many carcinomas, EMT-inducing signals, such as HGF, EGF, PDGF, and TGF-β, emanate from the tumor-associated stroma and activate a series of EMT-inducing transcription factors, including Snail, Slug, zinc finger E-box binding homeobox 1 (ZEB1), Twist, Goosecoid, and FOXC2.