GZMK and scoliosis: In patients with elbow contractures and scoliosis (sideways curving of the spine), an up-regulation of three inflammatory genes was found when compared with patients without those features, namely HLA-DRB1 and HLA-DRB5, (FC = 8.8, 7.1), and GZMK (FC = 1.3; FDR = 0%) (Figure 6).