SFMBT1, which encodes the drosophila sex comb on middle (scm)-like protein on 3p21.31 and contains four malignant brain tumor repeat domains, was simultaneously identified by our genome-wide GBAS [pCLRN = 1.82×10−10 (pFDRCLRN = 2.47×10−2) and pCLRN,BMI = 3.59×10−9 (pFDRCLRN,BMI = 2.81×10−2)], gene expression analysis [pANCOVA = 4.74×10−2], and a GBAS of the HKHS [pQFAMMBP = 1.36×10−5 (pFDRQFAMMBP = 3.44×10−2)]. The gene discussed is SFMBT1; the disease is brain cancer.