IGF1, another insulin-related gene which encodes insulin-like growth factor on 12q23.2, was associated with hypertension by GBAS and gene expression analyses of the TWNHS, successfully validated by GBAS of the HKHS in this study, and was previously associated with cardiovascular disorders [38], [39], [40], [41], [42] and metabolic disorders [43], [44], [45], [46], [47], [48], [49], [50], [51], [52]. Here, IGF1 is linked to metabolic disease.