ELN and vascular disorder: As it is shown in Figure 1, heart allografts placed into p110δD910A female recipients were protected from the development of vasculopathy as assessed by histopathologic criteria. Co-staining of elastine end SMC alpha actin revealed early signs of vasculopathy (narrowing of the lumen and perivascular proliferation of SMC [30]) in female WT recipient of male hearts, which was inhibited in p110δD910A female recipients (Figure 1A–B).