Our findings suggest that Drp-1 inhibitor, Mdivi-1 inhibits mitochondrial fission and thereby plays a role in a) ameliorating left ventricular dysfunction during heart failure, b) increases expression of CD31 and VEGF, thus angiogenesis, c) decreases expression of anti angiogenic factors and also minimizes collagen deposition, d) inhibits abnormal autophagy/mitophagy and also apoptosis. Here, VEGFA is linked to heart failure.