To compare the ability of the T9W and AnkT9W vectors to produce Hb in vivo, we engrafted mice affected by thalassemia intermedia (Hbbth3/+) [25], [26] with Hbbth3/+ BM cells transduced with either T9W or AnkT9W. This evidence concerns the gene GSTM1 and beta-thalassemia intermedia.