INS and obesity due to melanocortin 4 receptor deficiency: Independent efforts have also identified this locus in other metabolic/obesity related traits GWAS: first with WHR (rs2605100; r2 = 0.49 [21] and rs4846567; r2 = 0.55 [27] respectively with the lead adiponectin SNP, rs3001032), and more recently with fasting insulin by a joint meta-analysis including the interaction between SNP and BMI (MF Hivert for the MAGIC investigators, personal communication).