CAPN8 and autosomal recessive limb-girdle muscular dystrophy type 2A: Genetic association studies have implicated calpains in disease pathologies including limb-girdle muscular dystrophy type 2A (LGMD2A, CAPN3) [25], susceptibility to type II diabetes (CAPN10) [26] and gastric cancer (CAPN8/9) [27], [28].