When we examined these 29 renal function loci by age group, sex, diabetes and hypertension status (Tables S16, S17, S18, and S19), we observed consistent associations with eGFRcrea for most loci across all strata, with only two exceptions: UMOD had a stronger association in older individuals (P value for difference 8.4×10−13) and in those with hypertension (P value for difference 0.002), and CDK12 was stronger in younger subjects (P value for difference 0.0008). This evidence concerns the gene CDK12 and hypertensive disorder.