We have extended prior knowledge of common genetic variants for kidney function [8]–[11], [23] by performing genome-wide association tests within strata of key CKD risk factors, including age, sex, diabetes, and hypertension, thus uncovering 6 loci not previously known to be associated with renal function in population-based studies (MPPED2, DDX1, CASP9, SLC47A1, CDK12, INO80). This evidence concerns the gene CASP9 and diabetes mellitus.