Next, we performed bivariate analysis of cyclin E level along with key nodes in the b-Raf-ERK1/2-mTOR pathway, which revealed that among breast cancer patients with high LMW-E expression, those with high FAK levels had significantly worse DSS than those with low FAK levels (p = 0.0042) (Figure 7B and Figure S6). This evidence concerns the gene MAPK3 and breast cancer.