EGFR and familial pancreatic carcinoma: Overactivation of EGFR gives rise to the deregulation of this EGFR-dependent signaling network, which is involved in the development and malignancy of numerous types of human cancers including breast, head and neck, lung, bladder, colon, prostate, kidney, ovary, brain, and pancreatic cancers (Kolibaba and Druker 1997).