In another AD mouse model expressing the E693Δ mutation that causes AD by enhanced Aβ oligomerization without fibrillization, it was found that the mice displayed age-dependent accumulation of intraneuronal Aβ oligomers at around 8 months, when abnormal tau phosphorylation, and impairments of hippocampal synaptic plasticity and memory were observed. Here, MAPT is linked to Alzheimer disease.