INS and metabolic syndrome: Cox's proportional hazards model showed that higher BMI (RR 1.04; 95% CI: 1.03 and 1.05), higher education (RR 1.48; 95% CI: 1.29 and 1.69), and lower HbA1c (RR 0.90; 95% CI: 0.88 and 0.93), and treatment with insulin (RR 1.22; 95% CI: 1.10 and 1.35) or oral agent (RR 1.25; 95% CI: 1.09, 1.43) at baseline significantly predicted the onset of MetS after mean 11.7 years.