TRIM21 and systemic lupus erythematosus: It should be mentioned that there were also specific genes for one cluster that had a contribution of around 20% to their clusters, such as TRIM21 and TROVE2 in the cluster made up of SLE and SS, TPO in the cluster made up of T1D and AITD, and TNF in the cluster made up of RA and MS (Table 3).