CTLA4 and rheumatoid arthritis: The first was made up of HLA-DQB1, CD4, CTLA4 and FASLG that were genes connected through only one internode (TNFRSF25 is also connected through three internodes with FASLG) and the second subnetwork was made up of IL1B and IL10 that was connected to TNF, the gene with the highest contribution to the cluster made by RA and MS.