The importance of neurohormonal activation in the development and progress of cardiovascular disease processes such as CHD is well known, and the renin-angiotensin system plays a central role in this [32].The chronically activated renin-angiotensin aldosterone system (RAAS) is believed to contribute significantly to the deterioration of cardiovascular function, Inhibitors of it have been routinely used to treat patients with CHD [29]. Here, REN is linked to cardiovascular disorder.