INS and diabetes mellitus: When 2, 4, and 8 g/kg EEM and glibenclamide were administered for two weeks before induction of diabetes with streptozotocin and for a further 28 days afterwards, essentially similar effects were observed on blood glucose, serum insulin, ISI, serum TC, serum TG, glycogen, and TG contents in liver and skeletal muscle to those seen when EEM and glibenclamide were administered after induction of diabetes (data not shown).