INS and diabetes mellitus: In this study, the experiments were designed to detect the insulin sensitivity and hypoglycemic and hypolipidemic activities of ethanolic extract of Mirabilis jalapa L. root (EEM) on both diabetic and normal mice after induction with streptozotocin with both singly and repeatedly administration, and on diabetes before induction with repeatedly administration, and compared with glibenclamide as a reference standard.