TNF and neoplasm: In addition to targeting the antigen, tumor-specific scFv (single-chain fragment variable) could too deliver promising therapeutic agents such as tumor necrosis factor (TNF) and to be fused to interleukin-2 (IL-2) or superantigen Staphylococcal Enterotoxin B- for T-cell-mediated eradication of tumors [130, 131].