A CLTC-ALK-positive DLBCL cell line, generated from a patient with systemic relapsed disease, formed subcutaneous tumors in NOD-SCID mice, which morphologically and immunophenotypically recapitulated the ALK+ LBCL phenotype, including the granular cytoplasmic ALK staining pattern [14]. The gene discussed is ALK; the disease is diffuse large B-cell lymphoma.