The aim of this study was to evaluate vascular remodeling, inflammatory and oxidative stress markers, and atheroma development in high-fructose diet-induced insulin resistance of ApoE-deficient mice (ApoE-KO).Mice were fed with either a normal chow or a 10% w/v fructose (HF) in drinking water over a period of 8 weeks. The gene discussed is APOE; the disease is hydrops fetalis.