CHRNA7 and omphalocele: In particular, the apparently wide-spread expression of Chrna7:Cre in cell subsets throughout tissues of the developing fetus and the variety of potential defects in addition to SB (such as omphalocele, hematopoietic disruption, or reduced trunk size as noted in the Results section) indicates that the function of α7 is likely to exhibit considerable pleiotropy.