Interestingly, we previously observed that MMP-9 is involved in the VEGF-mediated neo-angiogenesis in colorectal cancer and that MMP-mediated endoglin mobilisation is involved in the regulation of the angiogenic potential of endothelial cells in colorectal cancer (Hawinkels et al, 2008; Hawinkels et al, 2010). The gene discussed is VEGFA; the disease is colorectal cancer.