These include: circulating antibodies or antigen-antibody complexes caused by the primary autoimmune disorder and inducing endothelial dysfunction [9]; platelet damage by TTP and production of autoantibodies [4]; deficiency of Von-Willebrand factor cleaving protease activity [10] or autoantibody against VWF cleaving protease [11]; molecular mimicry or redundancy of the immune system, also known as the kaleidoscope of immunity, which is the co-occurrence of various autoimmune diseases within an individual [12]. The gene discussed is VWF; the disease is endothelial dysfunction.