Recently, another possible mechanism for uncontrolled NF-kB activation in MALT lymphoma, particularly in the ocular adnexa, salivary gland and thyroid MALT lymphoma, is generated by homozygous deletion of the chromosomal band 6q23 with subsequent loss of the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) [104], an essential global NF-kB inhibitor. Here, TNFAIP3 is linked to thyroid gland disorder.