Analysis of specimens (n = 386) for which two punches from tumor center and periphery, respectively, were available, did not show any significant difference in infiltrate numbers for none of the markers under investigation: CD4 total (p = 0.951), CD4 intratumoral (p = 0.845), CD4 stromal (p = 0.297), FOXP3 total (p = 0.175), FOXP3 intratumoral (p = 0.11), FOXP3 stromal (p = 0.916), IL17 total (p = 0.292), IL-17 intratumoral and (p = 0.228) and IL17 stromal (p = 0.492). This evidence concerns the gene CD4 and neoplasm.