MAPK1 and familial pancreatic carcinoma: To determine whether there was a direct relation between SDC-2 expression levels and K-ras/MAPK, p120 and Src signaling, we silenced SDC-2 in Su8686, T3M4 and 8988 T pancreatic cancer cells and analyzed ras activity, levels of p120-GAP and phosphorylation of Src (Tyr416) and of ERK (Figure 4C).