SDC2 and cancer: In PDAC, different patterns of cellular/stromal distribution of SDC-2 were found: around some cancer structures, SDC-2 deposition was seen at different intensities (Figure 2, A6, 7) whereas some cancers showed only cytoplasmic cancer cell positivity for SDC-2 (Figure 2, A6; arrow); in other PDACs, nuclear SDC-2 staining was present (Figure 2, A7).