Expression of SREBF1 and its target HMGCR displayed significantly lower mRNA levels in the insulin-resistant group after 3 h (p < 0.05 and p < 0.001) and 6 h (p < 0.05 for both genes) of hyperinsulinemia (Figure 5E &5F). The gene discussed is SREBF1; the disease is Hyperinsulinemia.