Here, we showed that knock-down of OLFM4 effectively enhanced cell apoptosis in response to H2O2 or TNF α stimulation in MKN45 as well as SGC-7901 cells, suggesting blocking OLFM4 may increase the susceptibility of gastric cancer cells to the presence of H2O2 or TNF α. Here, OLFM4 is linked to gastric cancer.