Given the physiological locations of ephrin-B2 and -B3, the observed differences in the transmissibility of HeV and NiV and the differences in HeV and NiV disease course in susceptible hosts upon infection, additional study of the henipavirus G glycoproteins and their interaction with the ephrin receptors will further our understanding of the biology and pathology of these important zoonotic agents. Here, EFNB2 is linked to infection.