AKT1 and neoplasm: We thank Prof Siu-Wai Chiu (School of Life Sciences, The Chinese University of Hong Kong) for the authentication of the mushroom species, Dr L Larue (Developmental Genetics of Melanocytes, CNRS-Institut Curie) for providing the AKT plasmid and Prof Wing-Shing HO (School of Life Sciences, The Chinese University of Hong Kong) for providing the primary non-tumor hepatocelluar cell line WRL-68 as a gift.