CD8A and metastatic malignant neoplasm in the lymph nodes: It is demonstrated that EBVaGC have much more CD8+ CTL infiltrate than EBV-negative gastric carcinoma (EBVnGC) [51], [52], and that EBVaGC generally have lower frequency of lymph node metastases and better prognosis, suggesting a protective role for the CTL infiltrate [52].