When treated with amlodipine vs. lisinopril, the minor allele carriers at the NOS3 −690 locus showed lower risk of stroke (HR, 0.49 vs. 0.85; 95% CI, 0.31–0.80 vs. 0.73–0.99; P = 0.04), and the minor allele carriers at the glu298asp locus showed lower risk of all-cause mortality (HR, 0.85 vs. 1.01; 95% CI, 0.75–0.97 vs. 0.91–1.13, P = 0.04) compared to their respective wild type homozygous individuals. The gene discussed is NOS3; the disease is Stroke.