When minor allele carriers were combined (CT and CC for NOS3 −690 C>T, AG and GG for NOS3 −922 A>G, GT and TT for NOS3 glu298asp G>T), associations were found in the adjusted models between NOS3 −690 C>T and CHD, and NOS3 −922 A>G and heart failure (p<0.05). The gene discussed is NOS3; the disease is coronary artery disorder.