Minor allele carriers of NOS3 −690 C>T have higher risk of CHD (HR, 1.12; 95% CI, 1.00–1.26) and minor allele carriers of NOS3 −922 A>G have higher risk to heart failure (HR, 1.10; 95% CI, 1.00–1.21 compared to their respective wild-type homozygous individuals. The gene discussed is NOS3; the disease is heart failure.