Figure 3B shows that the EL4 lymphoma tumor growth was similar in RAGE−/− animals compared to controls 14 days after inoculation. We conclude from these experiments that the inhibition of tumor growth observed in the S100A9−/− mice might be dependent on interactions between S100A9 and TLR4 while RAGE may have no dominant role in this tumor model. This evidence concerns the gene TLR4 and neoplasm.