Conversely, cellular proliferation decreased when endogenous DACT1 expression was silenced by stable transfection with siRNA vectors that targeted DACT1 in the HCT116, LoVo and HT29 colon cancer cell lines, which have much higher endogenous levels of DACT1 (Figure 2B–D). The gene discussed is DACT1; the disease is colonic neoplasm.