We have shown that for nlp-29 cluster genes, following both infection and injury, inductive signaling passes via TPA-1, a protein kinase C delta (PKC∂) that acts upstream of TIR-1, the nematode ortholog of SARM, and a MAPK cassette comprising the MAP3K NSY-1, the MAP2K SEK-1, and PMK-1 [20]. Here, PRRT2 is linked to infection.