It is well known that wild-type male and female mice show differences in glucose tolerance [74], [75], and some recent studies have reported that male mice are more susceptible to developing glucose intolerance following Cre-loxP-mediated inactivation of critical β-cell genes such as FoxM1 and Ngn3 [76], [77]. The gene discussed is NEUROG3; the disease is Glucose intolerance.