Genome-wide association studies of sporadic ALS have implicated a number of genes or regions (DPP6, ITPR2, UNC13A, FGGY, ELP3, KIFAP3, 9p21.2) [3]–[11], but replication of these findings in independent populations has proven difficult [12]–[16]. The gene discussed is UNC13A; the disease is amyotrophic lateral sclerosis.