For example, recent data from a genomic sequence of HCC samples identified mutations in PIK3CA, an upstream regulator of Akt, in 50% of patients with poor prognosis and survival length < 3 years following partial liver resection, whereas only 10% of the HCC patients with a good prognosis had a mutation in PIK3CA [79]. Here, AKT1 is linked to hepatocellular carcinoma.