Moreover, accumulation of β-catenin in human HCC tumors containing the wild-type β-catenin gene has been observed in the context of up-regulation of the FZD7 receptor, which has been found up-regulated in 90% of human HCC [118-120], suggesting that FZD7 gene expression is the most common abnormality observed in HCC and consequently activation of Wnt/Frizzled-mediated signaling plays a key role in liver carcinogenesis. The gene discussed is FZD7; the disease is hepatocellular carcinoma.