As stated above, during the multistep biological process involved in the development of HCC several genetic and epigenetic alterations occur and various pathways are involved, including transforming growth factor (TGF)-β [197], hepatocyte growth factor (HGF)/c-MET [198-200], Hyppo [201] and Notch [202, 203] signaling. The gene discussed is HGF; the disease is hepatocellular carcinoma.