To confirm the dynamic alterations of protein abundance during infection with IBV ck/CH/LDL/97I P5 and ck/CH/LDL/97I P115, three proteins including annexin A2 (ANXA2), annexin A5 (ANXA5), and heat shock protein beta-1 (HSPB1) were selected for western blot analysis. The gene discussed is HSPB1; the disease is infection.