The most common irregularities of PCOS include elevated serum levels of free testosterone (T), androstenedione, dehydroepiandrosterone sulfate (DHEAS), excessive amount of luteinizing hormone (LH), elevated LH/FSH ratio, increase in LH peak pulse frequency and its response to GnRH (Gonadotropin-releasing hormone), and change in LH pulse frequency. Here, PLOD1 is linked to polycystic ovary syndrome.