An example of this was observed for the HDACi, SAHA, by altering the Th1/Th2 cytokine balance favouring Th1 by inhibiting STAT6-mediated IL-5 production and secretion of Thymus and Activation-Regulated Chemokine (TARC or CCL17) as well as increasing the levels of IL-10 and IL-13 in Hodgkin lymphoma cell lines in vitro [103]. This evidence concerns the gene CCL17 and Hodgkins lymphoma.