Using the murine model of MS, experimental autoimmune encephalomyelitis (EAE), the HDACi TSA reversed the myelin-oligodendrocyte-glycoprotein- (MOG-) induced EAE via proinflammatory cytokine repression as well as histone hyperacetylation and inhibition of axonal apoptosis by caspase-dependent mechanisms [86]. The gene discussed is MOG; the disease is myeloid sarcoma.