ESR1 and breast cancer: The recently reported GEICAM 2006-03-A study sought to determine the additional benefit of carboplatin to conventional neoadjuvant chemotherapy in women with TNBC/basal-like breast cancer patients (defined as ER−/PR−/HER2− and cytokeratin 5/6+ and/or epithelial growth factor receptor [EGFR]+) [15].