The recently reported National Surgical Adjuvant Breast and Bowel Project (NSABP) B-40 protocol asked two fundamental questions: (1) was the addition of the antimetabolite either capecitabine (X) or gemcitabine (G) to docetaxel (T) followed by AC, and/or (2) does the addition of bevacizumab to docetaxel/anthracycline-based regimens increase pCR rates for women with HER2-negative breast cancer [14]. This evidence concerns the gene ERBB2 and breast cancer.