In our case-control study, for the first time we investigated the associations between eight SNPs in the IL-17A (rs2275913, rs3819025 and rs3748067) and IL-17F (rs763780, rs7771511, rs12203582, rs9382084 and rs1266828) genes and the risk of sporadic breast cancer in Chinese Han women. This evidence concerns the gene IL17F and breast cancer.