We also determined the relationship between the polymorphisms in the IL-17A and IL-17F genes and several prognostic factors, including tumor protein 53 (P53), estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (Her-2) and triple-negative breast cancer (TNBC) in breast cancer patients. The gene discussed is ESR1; the disease is breast carcinoma.