As a result, compared to JWA+/+mice, only expressions of Elk1 at both mRNA (P<0.05) (Fig. 5A and Fig. S3A) and protein (Fig. 5B and Fig. S3B) levels were significantly down-regulated in JWAΔ2/Δ2 mouse papillomas and skin tissues. The gene discussed is ELK1; the disease is papilloma.