As we predicted, data showed the expressions of mRNA (P<0.01) (Fig. 3A), protein (Fig. 3B), and the amount of PCNA-positive cells in papillomas was significantly higher in JWA+/+ than in JWAΔ2/Δ2 mice (P<0.05) (Fig. 3C and D). The gene discussed is PCNA; the disease is papilloma.