RAD1 and neoplasm: Several DNA repair genes are involved in this step, such as Sirt1, Rad1, Rad9, etc. Rad1 and Rad9 are important for preventing tumor development, probably through maintaining genomic integrity [27], [28], while Sirt1 does not behave like a classical tumor-suppressor but partly participates the antitumor activity of resveratrol [29].