Consistent with this view, a decrease inTIF1γ expression in human pancreatic cancer and human chronic myelomonocyticleukemia has been reported [9], [11] and TIF1γ silencing in human mammary epithelial celllines was shown to lead to a strong epithelial-mesenchymal transition mediated byTGF-β1 [12].In contrast, a pro-tumorigenesis role for TIF1γ has been suggested by theobservation that its expression prevents Smad4-mediated growth inhibition inresponse to TGF-β [4]. Here, TRIM33 is linked to familial pancreatic carcinoma.