POLA1 and cancer: The majority of the downregulated genes, including ANKRD12, ASPM, CDC25A, CDCA4, CENPE, CHEK1, DLGAP5, DPP4, DTL, EBP, E2F8, FBXO5, FOLH1, HIST1H4C, HSP90B1, ITGAV, KIF14, MAD2L1, METAP2, NRIP1, POLA1, PRIM2, SKP2, TOP2A, TOP2B, TPR, and UHRF1, are associated with cell cycle function and cancer development [26, 27].