The majority of the downregulated genes, including ANKRD12, ASPM, CDC25A, CDCA4, CENPE, CHEK1, DLGAP5, DPP4, DTL, EBP, E2F8, FBXO5, FOLH1, HIST1H4C, HSP90B1, ITGAV, KIF14, MAD2L1, METAP2, NRIP1, POLA1, PRIM2, SKP2, TOP2A, TOP2B, TPR, and UHRF1, are associated with cell cycle function and cancer development [26, 27]. The gene discussed is SKP2; the disease is cancer.