TNFSF13B and Autoimmunity: BLyS overexpressing mice also present enlarged splenic MZ, B-cell hyperactivity and autoimmunity [35], a phenotype also shared by autoimmune-regulatory-(AIRE)-deficient mice, in which BLyS levels are elevated in serum and overexpressed by peripheral blood CD11c+ DC and stimulated bone marrow-derived DCs [36, 37].