TNFSF13B and HIV infectious disease: Based on these observations, it is tempting to speculate that in the context of HIV infection, the incapacity to keep a balance in homeostatic mucosal mDC populations, may allow for increased “proinflammatory” mDC, possibly overexpressing BLyS, to accumulate at mucosal sites, where they contribute to the imbalance of T regulatory/effector ratios and modulate the outcome of mucosal B-cell responses.