To evaluate the role of native Ets2 in the craniofacial and thymus phenotypes of DS, Hill et al. [36] used these mice to show that the reduction in Ets2 expression in these mice does not rescue thymus abnormalities, and mostly does not rescue cranial skeleton abnormalities, except for mesoderm-derived elements (the superoinfero height of the occipital bone is reduced by 16% in Ts65Dn, Ets2+/− versus euploid but is reduced by 4% in Ts65Dn versus euploid). This evidence concerns the gene ETS2 and Dravet syndrome.